Granulocyte-colony stimulating factor-producing gallbladder carcinoma-include analysis all case reports: A case
Wataru Izumo1, Kenji Furukawa2, Hideo Katsuragawa2
1Department of Surgery, Tama-Nanbu Chiiki Hospital, Tokyo Metropolitan Health and Medical Treatment Corporation, 2-1-2 Nakazawa, Tama, Tokyo 206-0036, Japan; Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
International Journal of Surgery Case Reports
|March 7, 2016
Summary
Gallbladder cancer rarely produces granulocyte-colony stimulating factor (G-CSF), leading to a poor prognosis. This case highlights that multidisciplinary therapy, including surgery and chemotherapy, may improve survival in patients with recurrent G-CSF-producing gallbladder carcinoma.
Area of Science:
- Oncology
- Gastroenterology
Background:
- Gallbladder carcinoma is rarely associated with granulocyte-colony stimulating factor (G-CSF) production.
- Tumors producing G-CSF typically have a poor prognosis.
Purpose of the Study:
- To report a rare case of G-CSF producing gallbladder carcinoma.
- To discuss the prognosis and treatment of this rare condition.
Main Methods:
- A 67-year-old male patient presented with fever and elevated leukocyte count.
- Diagnosis of G-CSF producing gallbladder carcinoma was confirmed via imaging and immunohistochemistry.
- The patient underwent surgical resection followed by chemotherapy (gemcitabine plus cisplatin).
Main Results:
- The patient survived for 16 months postoperatively with multidisciplinary therapy.
- Leukocyte count normalized after surgery and chemotherapy.
- Recurrence was observed, but chemotherapy led to normalization of leukocyte count.
Conclusions:
- G-CSF producing gallbladder carcinoma has a poor prognosis, with most patients dying within 12 months.
- Multidisciplinary therapy, including surgery and chemotherapy, may prolong survival in patients with recurrent G-CSF-producing gallbladder carcinoma.
