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Updated: Mar 24, 2026
Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
Published on: December 18, 2016
Simultaneous dynamic R2 R2', and R2* measurement using periodic π pulse shifting multiecho asymmetric spin echo
Chengyan Wang1, Rui Zhang2, Xiaodong Zhang3
1Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Purpose:
The purpose of this study was to demonstrate the feasibility of simultaneous dynamic R2 , R2', and R2* measurement of lower extremity muscle by means of a new method in which the periodic π pulse shifting multiecho asymmetric spin echo (psMASE) sequence is adopted together with a moving estimation (ME) strategy.
Theory And Methods:
The psMASE sequence is a modification of the multiecho asymmetric spin echo sequence determined by shifting the 180 ° refocusing pulse periodically. ME strategy is introduced to improve the temporal resolution of the simultaneous dynamic measurement of R2 , R2', and R2*. Reproducibility measurements and comparison with reference methods were conducted. Furthermore, this method was tested on 10 healthy volunteers with the dynamic imaging of lower extremity muscles during a cuff occlusion release paradigm.
Results:
Both phantom and in vivo comparisons demonstrated that psMASE-ME-based R2 and R2* had good agreement with those calculated by multiecho spin echo and gradient echo sequences. Scan-rescan tests showed good reproducibility. Moreover, muscle R2 , R2', and R2* increased obviously from rest to cuff occlusion and decreased significantly after cuff release.
Conclusion:
It is feasible to obtain high temporally resolved R2 , R2', and R2* simultaneously with the proposed psMASE-ME method. Magn Reson Med 77:766-773, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
