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Updated: Mar 24, 2026
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Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
Published on: November 7, 2020
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Factors Associated With Major Adverse Cardiovascular Events After Liver Transplantation Among a National Sample
L B VanWagner1,2, M Serper3, R Kang4
1Division of Gastroenterology & Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
Summary
Major adverse cardiovascular events (MACE) affect 11% of liver transplant recipients, impacting survival. Pre-transplant atrial fibrillation and stroke significantly increase MACE risk, identifying high-risk candidates.
Area of Science:
- Cardiology
- Hepatology
- Transplantation Medicine
Background:
- Major adverse cardiovascular events (MACE) assessment post-liver transplantation (LT) lacks multicenter data.
- Understanding MACE risk factors is crucial for improving LT outcomes.
Purpose of the Study:
- To assess factors associated with 30- and 90-day MACE after LT.
- To evaluate the impact of MACE on 1-year survival post-LT.
Main Methods:
- Analysis of an integrated database from University HealthSystem Consortium and Organ Procurement and Transplant Network (February 2002–December 2012).
- Multivariate Poisson regression used to identify MACE predictors.
- MACE defined as myocardial infarction, heart failure, atrial fibrillation, cardiac arrest, pulmonary embolism, and/or stroke.
Main Results:
- MACE occurred in 8% (30-day) and 11% (90-day) of 32,810 LT recipients.
- Independent MACE predictors included age >65, alcoholic cirrhosis, NASH, elevated creatinine, baseline AF, and stroke.
- MACE was linked to significantly lower 1-year survival (79% vs. 88%).
Conclusions:
- MACE impacts 11% of LT recipients and negatively affects survival.
- Pre-LT atrial fibrillation and stroke are substantial MACE risk factors.
- Identifies high-risk LT candidates for closer cardiovascular monitoring.
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