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Updated: Mar 24, 2026

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
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Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

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Contribution of inflammasome genetics in Plasmodium vivax malaria

Marina L S Santos1, Edione Cristina Reis2, Pamela N Bricher2

  • 1Laboratório de Malária, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil.

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
|March 7, 2016
PubMed

Insights

Inflammasome gene variations influence Plasmodium vivax malaria severity. NLRP1 receptor genetics impact fever, anemia, and thrombocytopenia, while IL18 offers protection against anemia in patients.

Area of Science:

  • Immunology
  • Genetics
  • Infectious Diseases

Background:

  • Symptomatic Plasmodium infection in mice activates inflammasomes.
  • Inflammasome activation in human malaria is less understood.
  • Plasmodium vivax is a potent inducer of inflammatory responses.

Purpose of the Study:

  • To investigate if inflammasome gene polymorphisms affect Plasmodium vivax malaria clinical presentation.
  • To analyze the association between single nucleotide polymorphisms (SNPs) in inflammasome genes and clinical parameters in P. vivax malaria patients.

Main Methods:

  • Genotyping of 157 Brazilian Amazon patients with P. vivax malaria for 10 SNPs in inflammasome genes (NLRP1, NLRP3, AIM2, CARD8, IL1B, IL18, MEFV).
  • Multivariate analysis to assess the effect of SNPs on hematologic and clinical parameters.

Main Results:

  • NLRP1 inflammasome receptor genetics significantly influenced the clinical presentation, including fever, anemia, and thrombocytopenia.
  • IL1B rs1143634 SNP was associated with patient parasitemia.
  • IL18 rs5744256 SNP demonstrated a protective role against anemia development.

Conclusions:

  • Inflammasome gene polymorphisms can modulate various aspects of malaria pathogenesis.
  • These findings reveal novel P. vivax/host interactions involving the NLRP1 inflammasome.
  • Genetic variations in inflammasome pathways may impact P. vivax malaria outcomes.
Keywords:
IL18IL1BInflammasomeMalariaNLRP1NLRP3P. vivax

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