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Related Experiment Video

Updated: Mar 24, 2026

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing

Published on: June 9, 2017

Nuclear Factor Erythroid-2 Like 1 (NFE2L1): Structure, function and regulation.

Hyun Min Kim¹, Jeong Woo Han¹, Jefferson Y Chan¹

¹Department of Laboratory Medicine and Pathology, University of California, Irvine, D440 Medical Sciences, Irvine, CA 92697, USA.

|March 8, 2016

Summary

Nuclear factor erythroid 2-related factor 1 (Nrf1) is a key transcription factor regulating cellular functions like stress response and metabolism. This review details Nrf1

Keywords:

Antioxidant Antioxidant response element CNC-bZIP Cellular stress response Proteostasis Transcription factor proteasome regulation

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Measurements of Physiological Stress Responses in C. Elegans

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Published on: May 21, 2020

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Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing

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Published on: June 9, 2017

Measurements of Physiological Stress Responses in C. Elegans

Measurements of Physiological Stress Responses in C. Elegans

Published on: May 21, 2020

Area of Science:

Molecular biology
Cellular signaling
Transcription factors

Background:

Nuclear factor erythroid 2-related factor 1 (Nrf1), also known as NFE2L1, belongs to the CNC-bZIP transcription factor family.
Nrf1 is characterized by conserved CNC and basic-leucine zipper domains crucial for its function.
It is widely expressed and its activity is induced by various stress signals.

Purpose of the Study:

To review the current understanding of Nrf1.
To elucidate the molecular mechanisms regulating Nrf1.
To explore Nrf1's role in diverse cellular functions.

Main Methods:

Literature review of existing studies on Nrf1.
Analysis of molecular pathways involved in Nrf1 regulation.
Synthesis of data on Nrf1's function in cellular processes.

Main Results:

Nrf1 regulates critical cellular functions including oxidative stress response, differentiation, inflammation, metabolism, and proteostasis.
Aberrant Nrf1 activity is linked to diseases such as cancer and metabolic disorders.
Nrf1 exists in various isoforms, contributing to its diverse roles.

Conclusions:

Nrf1 is a vital transcription factor with broad implications in cellular health and disease.
Understanding Nrf1's regulation and function is crucial for developing therapeutic strategies.
Further research into Nrf1 mechanisms can uncover new insights into disease pathogenesis.