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Primary Urinary Bladder Angiosarcoma with Osteoclast-Like Multinucleated Giant Cells: A Case Report and Literature
Nariman A Nawar1, Jamie Olsen2, Tomislav M Jelic3
1Department of Pathology, West Virginia University, Morgantown, WV, USA.
The American Journal of Case Reports
|March 8, 2016
Summary
Primary urinary bladder angiosarcoma is a rare and aggressive cancer. This case report highlights a unique variant with osteoclast-like giant cells, aiding diagnosis of this challenging malignancy.
Area of Science:
- Oncology
- Pathology
- Urology
Background:
- Angiosarcoma is a rare, aggressive mesenchymal tumor with limited reported cases in the urinary bladder.
- Primary urinary bladder angiosarcoma is exceptionally uncommon, with only 13 cases previously documented.
Observation:
- A 68-year-old male presented with urinary retention due to a bladder mass.
- Imaging revealed a significant urinary bladder mass requiring surgical intervention.
- Pathological examination confirmed angiosarcoma, notably featuring abundant osteoclast-like multinucleated giant cells.
Findings:
- The diagnosed angiosarcoma exhibited an unusual histological pattern rich in osteoclast-like multinucleated giant cells.
- This presentation differs from previously reported primary urinary bladder angiosarcomas.
- Diagnosis of primary urinary bladder angiosarcoma is complex due to variable histology and immunophenotypes.
Implications:
- This case expands the understanding of angiosarcoma variants in the urinary bladder.
- Recognizing diverse histological features is crucial for accurate diagnosis and patient management.
- Further research into rare bladder cancers can improve diagnostic strategies and treatment outcomes.
