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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Translating gastric cancer genomics into targeted therapies

Yvonne L E Ang1, Wei Peng Yong2, Patrick Tan3

  • 1Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore.

Critical Reviews in Oncology/Hematology
|March 8, 2016
PubMed

Insights

Gastric cancer treatment is improving with targeted therapies and immunotherapy, driven by molecular classification. Biomarker development is key for future clinical success in this challenging disease.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Gastric cancer presents limited treatment options and a poor prognosis.
  • Many gastric cancers possess actionable targets like tyrosine kinase pathways (e.g., HER2).
  • High somatic mutation rates suggest potential for immunotherapy in gastric cancer.

Purpose of the Study:

  • To review recent advances in gastric cancer molecular classification and targeted therapy.
  • To highlight the role of molecular profiling in guiding treatment selection.
  • To discuss challenges and future directions in precision medicine for gastric cancer.

Main Methods:

  • Review of current literature on gastric cancer genomics and targeted therapies.
  • Analysis of clinical trial data for agents targeting specific molecular alterations.
  • Examination of advancements in whole genome and multi-platform sequencing.

Main Results:

  • Trastuzumab has shown survival benefits in HER2-overexpressing gastric cancers.
  • Immunotherapy shows promise due to high somatic mutation rates in gastric tumors.
  • Molecular classification systems are emerging to guide targeted treatment selection.

Conclusions:

  • Precision medicine approaches, guided by molecular classification, are transforming gastric cancer treatment.
  • Development of predictive biomarkers is crucial for optimizing targeted therapy efficacy.
  • Integrating molecular insights into clinical trials and practice is essential for advancing patient care.
Keywords:
Gastric cancerImmunotherapyMolecular classificationTargeted therapy

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