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Updated: Mar 24, 2026
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An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
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[Intestinal microbiota and ageing: A new intervention route?]
1Hospital Clínico San Carlos, Facultad de Medicina, Universidad Complutense, Madrid, España.
Revista Espanola De Geriatria Y Gerontologia
|March 8, 2016
Summary
The aging process significantly impacts the intestinal microbiota (IM), leading to changes that affect health. Diet and other factors influence these shifts, with potential for positive interventions.
Area of Science:
- Gastroenterology
- Microbiology
- Gerontology
Background:
- The intestinal microbiota (IM) is crucial for health and undergoes changes throughout the human life cycle.
- Factors influencing IM composition and function are increasingly understood.
- Aging involves complex physiological changes, including those within the gut environment.
Purpose of the Study:
- To review the current understanding of the relationship between intestinal microbiota and aging.
- To explore factors contributing to age-related changes in the gut microbiome.
- To discuss the health consequences of these microbial shifts and potential interventions.
Main Methods:
- Literature review focusing on aging, gut changes, and intestinal microbiota.
- Analysis of factors affecting IM during aging (physiology, disease, environment, diet, drugs).
- Examination of health outcomes and potential interventions, particularly dietary.
Main Results:
- Aging is associated with significant alterations in intestinal microbiota composition and function.
- Factors such as disease, environment, diet, and medications profoundly influence age-related IM changes.
- These microbial shifts have direct consequences for the health and well-being of older adults.
Conclusions:
- Understanding age-related intestinal microbiota changes is vital for geriatric health.
- Positive interventions, especially dietary strategies, show promise in modulating the aging microbiome.
- Further research into targeted interventions can improve health outcomes in aging populations.
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