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Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
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Sirtuins, Cell Senescence, and Vascular Aging
Yujiro Kida1, Michael S Goligorsky1
1Departments of Medicine, Pharmacology, and Physiology, Renal Research Institute, New York Medical College, Valhalla, New York, USA.
The Canadian Journal of Cardiology
|March 8, 2016
Summary
Sirtuins (SIRTs) are proteins involved in cell aging. SIRT1, SIRT3, and SIRT6 show protective effects against vascular aging, offering potential cardiovascular disease therapies, though clinical trials are ongoing.
Area of Science:
- Biochemistry
- Molecular Biology
- Gerontology
Background:
- Sirtuins (SIRTs) are NAD+-dependent enzymes with deacetylase or ADP-ribosyltransferase activity.
- Seven mammalian SIRT family members (SIRT1-7) exist, with varying cellular localizations and established roles in cellular functions and stress responses.
- Vascular aging, characterized by endothelial and smooth muscle cell senescence, contributes to cardiovascular diseases.
Purpose of the Study:
- To review the role of sirtuins in vascular aging.
- To explore the therapeutic potential of SIRT modulation for cardiovascular diseases.
- To summarize current clinical evidence and ongoing trials for SIRT-based therapies.
Main Methods:
- Literature review of mechanistic studies on SIRT proteins and vascular aging.
- Analysis of existing pilot human studies on SIRT modulation.
- Overview of ongoing clinical trials investigating SIRT modulators and activators.
Main Results:
- SIRT1, SIRT3, and SIRT6 have demonstrated protective functions against vascular aging.
- SIRT modulation and NAD+ stimulation are promising therapeutic strategies for cardiovascular diseases.
- Current clinical evidence for SIRT-based therapies in cardiovascular disease is limited, with ongoing trials expected to provide further insights.
Conclusions:
- Sirtuins play a significant role in regulating vascular aging processes.
- Targeting sirtuins presents a promising avenue for cardiovascular disease treatment.
- Further clinical investigation is crucial to establish the efficacy and safety of SIRT modulators in patients with cardiovascular diseases.
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