Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiplexed dopamine neurons predominate in the ventral midbrain of young macaques.

bioRxiv : the preprint server for biology·2026
Same author

Microglial interferon signaling and Aβ plaque pathology are enhanced in female 5xFAD Alzheimer's disease mice, independent of estrous cycle stage.

Journal of neuroinflammation·2025
Same author

Noradrenergic signaling controls Alzheimer's disease pathology via activation of microglial β2 adrenergic receptors.

Brain, behavior, and immunity·2025
Same author

Partial microglial depletion and repopulation exert subtle but differential effects on amyloid pathology at different disease stages.

Scientific reports·2024
Same author

Amygdalo-nigral inputs target dopaminergic and GABAergic neurons in the primate: a view from dendrites and soma.

bioRxiv : the preprint server for biology·2024
Same author

Association of self-directed walking with toxicity moderation during chemotherapy for the treatment of early breast cancer.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2023

Related Experiment Video

Updated: Mar 24, 2026

Simultaneous Two-photon In Vivo Imaging of Synaptic Inputs and Postsynaptic Targets in the Mouse Retrosplenial Cortex
16:45

Simultaneous Two-photon In Vivo Imaging of Synaptic Inputs and Postsynaptic Targets in the Mouse Retrosplenial Cortex

Published on: March 13, 2016

12.1K

Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex.

G O Sipe1,2, R L Lowery1,2, M-È Tremblay1

  • 1Department of Neuroscience, University of Rochester, 601 Elmwood Avenue, box 603, Rochester, New York 14642, USA.

Nature Communications
|March 8, 2016
PubMed
Summary
This summary is machine-generated.

Microglia, the brain's immune cells, are crucial for ocular dominance plasticity. Disrupting the P2Y12 receptor in microglia blocks this experience-dependent brain plasticity during development.

More Related Videos

Laser-scanning Photostimulation of Optogenetically Targeted Forebrain Circuits
07:43

Laser-scanning Photostimulation of Optogenetically Targeted Forebrain Circuits

Published on: December 27, 2013

9.8K
Pentylenetetrazole-Induced Kindling Mouse Model
07:06

Pentylenetetrazole-Induced Kindling Mouse Model

Published on: June 12, 2018

35.4K

Related Experiment Videos

Last Updated: Mar 24, 2026

Simultaneous Two-photon In Vivo Imaging of Synaptic Inputs and Postsynaptic Targets in the Mouse Retrosplenial Cortex
16:45

Simultaneous Two-photon In Vivo Imaging of Synaptic Inputs and Postsynaptic Targets in the Mouse Retrosplenial Cortex

Published on: March 13, 2016

12.1K
Laser-scanning Photostimulation of Optogenetically Targeted Forebrain Circuits
07:43

Laser-scanning Photostimulation of Optogenetically Targeted Forebrain Circuits

Published on: December 27, 2013

9.8K
Pentylenetetrazole-Induced Kindling Mouse Model
07:06

Pentylenetetrazole-Induced Kindling Mouse Model

Published on: June 12, 2018

35.4K

Area of Science:

  • Neuroscience
  • Immunology
  • Developmental Biology

Background:

  • Microglia are brain-resident immune cells involved in neurophysiology and development.
  • Ocular dominance plasticity involves changes in visual cortex connections during a critical period.

Purpose of the Study:

  • To investigate the role of microglia in ocular dominance plasticity.
  • To explore the involvement of the P2Y12 receptor in microglial responses and plasticity.

Main Methods:

  • Monocular deprivation in adolescent mice.
  • Analysis of microglial morphology, motility, and synaptic interactions.
  • Genetic disruption of the P2Y12 receptor.

Main Results:

  • Microglia alter morphology, motility, and synaptic interactions during monocular deprivation.
  • Disruption of the P2Y12 receptor impairs microglial response to deprivation.
  • P2Y12 receptor disruption abrogates ocular dominance plasticity.

Conclusions:

  • Microglia are essential for ocular dominance plasticity.
  • The P2Y12 receptor mediates microglial functions critical for this plasticity.
  • Microglia actively shape experience-dependent brain plasticity.