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The interaction between histamine H1 receptor and μ- opioid receptor in scratching behavior in ICR mice
Tasuku Nakasone1, Yumi Sugimoto1, Chiaki Kamei1
1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Yasuda Women's University, 6-13-1, Yasuhigashi, Asaminami-Ku, Hiroshima 731-0153, Japan.
Abstract:
In this study, we examined the interaction between histamine H1 receptor and μ-opioid receptor in scratching behavior in ICR mice. Both histamine and morphine caused scratching and simultaneous injection of histamine and morphine had an additive effect. Chlorpheniramine and naloxone inhibited histamine-induced scratching behavior. These two drugs also inhibited morphine-induced scratching behavior. Simultaneous injection of chlorpheniramine and naloxone caused a significant inhibition of histamine-induced scratching compared with separate injections. The same findings were also noted for morphine-induced scratching. These results strongly indicate a close relationship between histamine H1 receptor and μ-opioid receptor in scratching behavior in ICR mice.
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