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Updated: Mar 24, 2026
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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
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Principles of immunotherapy
Brandon D Liebelt1, Gaetano Finocchiaro2, Amy B Heimberger3
1Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA; Houston Methodist Neurological Institute, Houston, TX, USA.
Handbook of Clinical Neurology
|March 8, 2016
Summary
Novel immunotherapies, including vaccination and cellular therapies, show promise for treating aggressive gliomas. Combining these approaches with traditional treatments may offer the best strategy for overcoming tumor heterogeneity and improving patient outcomes.
Area of Science:
- Neuro-oncology
- Immunology
- Cancer Therapy
Background:
- Gliomas are primary brain tumors with poor prognoses.
- The central nervous system immune microenvironment presents challenges for cancer treatment.
Purpose of the Study:
- To review emerging immunotherapeutic strategies for glioma treatment.
- To highlight the potential of novel immune-based approaches for glioblastoma.
Main Methods:
- Review of current and investigational immunotherapies for gliomas.
- Discussion of strategies including vaccination, adoptive cell therapy, chimeric antigen receptors, bispecific antibodies, aptamers, and checkpoint blockade.
Main Results:
- Multiple immunotherapeutic modalities are under investigation for glioblastoma.
- These approaches aim to leverage the immune system to combat tumor growth and evasion.
Conclusions:
- Immunotherapy offers a promising avenue for adjuvant treatment of gliomas.
- Multifaceted treatment strategies combining various immunotherapies and conventional therapies are essential for overcoming glioblastoma heterogeneity and improving efficacy.
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