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Published on: June 13, 2016
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Tocotrienol and cancer metastasis.
Leanne De Silva1, Lay Hong Chuah1, Puvaneswari Meganathan2
1School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia.
Biofactors (Oxford, England)
|March 8, 2016
Summary
Tocotrienols (T3), a form of vitamin E, show promise in combating cancer metastasis. These compounds modulate key processes like invasion, angiogenesis, and inflammation, offering potential therapeutic strategies against cancer spread.
Area of Science:
- Oncology
- Nutritional Science
- Molecular Biology
Background:
- Cancer metastasis is a complex process leading to poor prognosis.
- Research in vitamin E has shifted towards tocotrienols (T3) for their anti-cancer properties.
Purpose of the Study:
- To review the anti-metastatic roles of tocotrienols (T3) in cancer progression.
- To explore T3's impact on each stage of the metastatic cascade.
Main Methods:
- Literature review of recent studies on tocotrienols and cancer metastasis.
- Analysis of T3's effects on signaling pathways, extracellular matrix, cell motility, angiogenesis, and inflammation.
Main Results:
- Tocotrienols (T3) modulate signaling pathways involved in tumor cell invasion and extracellular matrix degradation.
- T3 show potential in suppressing angiogenesis, a critical step in metastasis.
- The anti-inflammatory effects of T3 may regulate the tumor microenvironment, inhibiting distant tumor growth.
Conclusions:
- Tocotrienols (T3) exhibit significant anti-metastatic properties.
- T3 represent a promising therapeutic avenue for preventing and managing cancer metastasis.
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