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New IVIVE method for the prediction of total human clearance and relative elimination pathway contributions from in

Julia Riede1, Birk Poller2, Ken-ichi Umehara2

  • 1Division of Drug Metabolism and Pharmacokinetics, Integrated Drug Disposition Section, Novartis Institutes for BioMedical Research, CH-4056 Basel, Switzerland; Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel, CH-4056 Basel, Switzerland.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|March 8, 2016
PubMed

Keywords:
Aliskiren (PubChem CID: 5493444)Atorvastatin (PubChem CID: 60823)Clearance predictionCyclosporine A (PubChem CID: 5284373)Digoxin (PubChem CID: 2724385)Extended Clearance Concept Classification System (ECCCS)Hepatic uptakeIn vitro–in vivo extrapolation (IVIVE)Ketoconazole (PubChem CID: 47576)Pitavastatin (PubChem CID: 5282452)Pravastatin (PubChem CID: 54687)Quinidine (PubChem CID: 441074)Simvastatin acid (PubChem CID: 64718)Valsartan (PubChem CID: 60846)

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