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[Decrease in toxicity and therapeutic effect of zoledronic acid in combination therapy with different antioxidant
José Antonio Lopez-Morata1, Amparo Olivares1, Miguel Alcaraz1
1Departamento de Radiología, Facultad de Medicina/Odontología, Universidad de Murcia, Campus Espinardo, Murcia, España; Departamento de Medicina Física, Facultad de Medicina/Odontología, Universidad de Murcia, Campus Espinardo, Murcia, España.
Revista Espanola De Geriatria Y Gerontologia
|March 8, 2016
Summary
Antioxidants protect normal prostate cells from zoledronic acid but not tumor cells. Rosmarinic acid and apigenin protect both normal and tumor cells from ionizing radiation, potentially reducing therapeutic effects.
Area of Science:
- Oncology
- Cell Biology
- Radiotherapy
Background:
- Zoledronic acid is used for cancer but can cause osteonecrosis.
- Investigating protective effects of antioxidants against zoledronic acid and radiation side effects.
Purpose of the Study:
- Evaluate antioxidants' protective effects on prostate cells (PNT2, TRAMP-C1) against zoledronic acid and ionizing radiation (IR).
- Assess combined treatments of zoledronic acid, IR, and antioxidants.
Main Methods:
- Cell viability assays (MTT) were used to study PNT2 and TRAMP-C1 cell survival.
- Tested isolated and combined treatments with zoledronic acid, IR, and three antioxidant substances.
Main Results:
- Zoledronic acid showed significant cytotoxicity in both cell lines (P<.001).
- Antioxidants protected normal prostate cells but not tumor cells from zoledronic acid.
- Rosmarinic acid and apigenin protected both normal and tumor cells from ionizing radiation damage.
Conclusions:
- Antioxidants can mitigate zoledronic acid's cytotoxic effects on non-tumor cells, suggesting use in benign conditions.
- In combined IR treatments, antioxidants protected tumor cells, potentially compromising the therapeutic outcome.
Keywords:
Efectos de la radiaciónEffects of radiationRadio-protectiveRadio-sensitisingRadioprotectoresRadiosensibilizantesZoledronic acidÁcido zoledrónicoMore Related Videos
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