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Social dysfunction after pediatric traumatic brain injury: A translational perspective
Nicholas P Ryan1, Cathy Catroppa2, Celia Godfrey3
1Australian Centre for Child Neuropsychological Studies, Murdoch Childrens Research Institute, Parkville, VIC, Australia; Melbourne School of Psychological Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia.
Neuroscience and Biobehavioral Reviews
|March 8, 2016
Summary
Social dysfunction after traumatic brain injury (TBI) is common, especially in children. Research in humans and rodents highlights disrupted brain networks and neuroendocrine function as key factors, informing future prevention strategies.
Area of Science:
- Neuroscience
- Developmental Biology
- Psychology
Background:
- Social dysfunction is a significant challenge for traumatic brain injury (TBI) survivors, impacting quality of life.
- Understanding factors influencing social deficits after TBI, particularly during childhood and adolescence, is crucial but remains limited.
Purpose of the Study:
- To review current knowledge on social dysfunction following TBI in humans and rodent models.
- To focus on TBI acquired during early development and identify mechanisms underlying social impairments.
Main Methods:
- Literature review of clinical and experimental studies on TBI and social behavior.
- Analysis of rodent models of TBI to investigate neurobiological underpinnings.
- Discussion of risk and resilience factors influencing social outcomes.
Main Results:
- Aberrant social interactions are observable in rodent models of TBI.
- Disrupted social brain network connectivity and aberrant neuroendocrine function are potential mechanisms for pediatric TBI-related social impairments.
- Overlap and disparities exist between human and rodent study findings.
Conclusions:
- Pediatric TBI can lead to persistent social deficits.
- Understanding neurobiological mechanisms like network disruption and neuroendocrine changes is key.
- Future research should focus on translational approaches for prevention and amelioration of social dysfunction after childhood TBI.
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