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Irreversible Electroporation as an Effective Technique for Ablating Human Metastatic Osteosarcoma
Jamie C Harris1, Allen Chen, Virgilia Macias
1Departments of *Surgery †Interventional Radiology §Pathology, Rush University Medical Center ‡Department of Pathology, University of Illinois at Chicago, Chicago, IL.
Journal of Pediatric Hematology/Oncology
|March 8, 2016
Summary
Irreversible electroporation (IRE) effectively treated pediatric metastatic osteosarcoma in a resected tumor sample. Optimal voltage was determined to be 2200 kV, showing potential for unresectable tumors.
Area of Science:
- Oncology
- Biophysics
- Medical Engineering
Background:
- Metastatic osteosarcoma (OS) presents a challenge in pediatric oncology.
- Unresectable tumors often require innovative treatment modalities.
- Irreversible electroporation (IRE) is an emerging technique utilizing electric fields to induce cell death.
Observation:
- A 12-year-old patient with metastatic OS underwent surgical resection.
- IRE was applied to a resected tumor specimen to assess treatment parameters.
- Electrical parameters, including voltage and current draw, were monitored during IRE application.
Findings:
- A voltage of 2200 kV with 100 pulses (90 ms width) resulted in a significant current draw increase (9 amps), indicating successful IRE.
- Histological analysis revealed tumor cell destruction, edema, and hemorrhage in the treated sample.
- Variations in electrical conductivity, particularly in aerated lung tissue, influenced optimal voltage requirements.
Implications:
- IRE demonstrates potential as a treatment option for unresectable pediatric metastatic osteosarcoma.
- Further research is needed to optimize IRE parameters for lung tissue and similar conditions.
- This study provides critical data on IRE efficacy and voltage optimization in a relevant preclinical model.
