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Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
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Perspectives for immunotherapy: which applications might achieve an HIV functional cure?
Vincent Vieillard1, Shahin Gharakhanian2, Olivier Lucar1,3
1Sorbonne Universités, UPMC Université Paris 06, INSERM, CNRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France.
Oncotarget
|March 8, 2016
Summary
New immunotherapies aim to enhance combined antiretroviral therapy (cART) for better HIV control. These strategies explore vaccines, antibodies, and cytokines to boost immune responses against persistent HIV reservoirs.
Area of Science:
- Immunology
- Virology
- Therapeutics
Background:
- Combined antiretroviral therapy (cART) effectively controls HIV replication but has limitations.
- Limitations include lifelong treatment, incomplete immune restoration, chronic inflammation, and persistent viral reservoirs.
Purpose of the Study:
- To review novel immunotherapeutic strategies as adjuncts to cART.
- To explore approaches for complete HIV containment, especially upon cART discontinuation.
Main Methods:
- Review of recent research on immunotherapeutic options for HIV.
- Examination of vaccine strategies using mosaic antigens and conserved peptides.
- Analysis of broadly neutralizing antibodies and their enhanced properties.
Main Results:
- Promising cytokines, vaccine strategies, and antibody-based therapies are emerging.
- These approaches aim to improve immune control over HIV.
- Combination therapies with TLR-agonists show potential.
Conclusions:
- Novel immunotherapies offer potential for complete HIV containment.
- These strategies may overcome challenges posed by immune activation and viral persistence.
- Further investigation is warranted for potentiating immune responses against HIV.
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