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Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Updated: Mar 24, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion
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Cell therapy in chronic liver disease.

Clara T Nicolas1, Yujia Wang, Scott L Nyberg

  • 1aWilliam J. von Liebig Center for Transplantation and Clinical RegenerationbDepartment of Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Current Opinion in Gastroenterology
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Cell therapy offers a promising alternative for chronic liver disease, with stem cells reducing fibrosis and bioartificial devices supporting liver function. These regenerative medicine approaches may soon provide alternatives or bridges to liver transplantation.

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Area of Science:

  • Regenerative Medicine
  • Hepatology
  • Cell Therapy

Background:

  • Liver transplantation is the only cure for end-stage liver disease but is limited by organ availability.
  • Cell therapy and bioartificial liver devices present potential alternatives or bridging strategies.
  • Chronic liver disease necessitates innovative treatment approaches beyond transplantation.

Purpose of the Study:

  • To review recent advances in cell therapy and regenerative medicine for chronic liver disease.
  • To highlight potential therapeutic strategies for liver disease treatment.
  • To discuss the future role of cell-based therapies in liver regeneration.

Main Methods:

  • Review of current literature on cell transplantation and bioartificial liver devices.
  • Analysis of studies involving hepatocyte transplantation and stem cell applications.
  • Evaluation of bioartificial liver device development and efficacy.

Main Results:

  • Hepatocyte transplantation can achieve long-term engraftment, enhanced by preconditioning and inflammatory blockade.
  • Mesenchymal stem cells show potential in reducing liver fibrosis and promoting regeneration.
  • Adipose tissue-derived stem cells are being explored due to accessibility.
  • Bioartificial liver devices demonstrate efficacy in preserving hepatocytes and improving survival in animal models.

Conclusions:

  • Cell transplantation using hepatocytes or stem cell-derived cells shows promise for chronic liver disease.
  • Bioartificial liver systems may serve as a bridge to transplantation for acute-on-chronic liver failure.
  • Regenerative medicine holds significant potential for future liver disease management.