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Updated: Mar 24, 2026

Inducible and Reversible Dominant-negative DN Protein Inhibition
Published on: January 7, 2019
Self-DNA inhibitory effects: Underlying mechanisms and ecological implications
Fabrizio Cartenì1, Giuliano Bonanomi1, Francesco Giannino1
1a Dipartimento di Agraria , University of Naples Federico II , via Università 100, Portici ( NA ), Italy.
Abstract:
DNA is usually known as the molecule that carries the instructions necessary for cell functioning and genetic inheritance. A recent discovery reported a new functional role for extracellular DNA. After fragmentation, either by natural or artificial decomposition, small DNA molecules (between ∼50 and ∼2000 bp) exert a species specific inhibitory effect on individuals of the same species. Evidence shows that such effect occurs for a wide range of organisms, suggesting a general biological process. In this paper we explore the possible molecular mechanisms behind those findings and discuss the ecological implications, specifically those related to plant species coexistence.
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