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Anterior-Chamber Angle and Axial Length Measurements in Normal Chinese Children
Peiyao Jin1, Meili Li, Xiangui He
1*Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University †Department of Preventative Ophthalmology, Shanghai Eye Hospital, Shanghai Eye Disease Prevention and Treatment Center, Shanghai, China ‡Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, FL.
Insights
Axial length (AL) and anterior chamber angle measurements in Chinese children aged 7-15 increase with age. Angle width is associated with anterior chamber depth (ACD) and age.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Biometry
Background:
- Understanding ocular biometry in children is crucial for monitoring refractive development.
- Anterior chamber parameters and axial length (AL) are key indicators of ocular growth and refractive status.
- Limited data exists on the physiological distribution of these parameters in Chinese pediatric populations.
Purpose of the Study:
- To determine the normative distribution of anterior chamber angle parameters and AL in a randomly selected cohort of Chinese children.
- To investigate the associations between age, sex, refractive error, iris thickness, AL, anterior chamber depth (ACD), and angle measurements.
Main Methods:
- Prospective, cross-sectional study involving 541 randomly sampled Chinese children aged 7-15 years.
- Comprehensive ophthalmologic examinations including anterior segment parameter and AL measurements using Fourier-domain optical coherence tomography and automated biometry.
- Statistical analysis using multiple correlation, regression tests, and linear regression to assess associations between variables.
Main Results:
- Axial length (AL) showed a logarithmic increase with age (P<0.01).
- Angle measurements increased with age and were positively correlated with anterior chamber depth (ACD) (P<0.001).
- Boys exhibited longer AL compared to girls (P<0.01), with no significant sex differences in angle parameters.
Conclusions:
- Anterior chamber angle measurements and AL exhibit age-dependent changes in Chinese children.
- Age and ACD are significant independent predictors of anterior chamber angle width.
- Findings provide normative data for pediatric ocular biometry in this population.
Purpose:
To establish the physiological distribution of anterior-chamber angle parameters and axial length (AL) in a randomly sampled cohort of Chinese children.
Patients And Methods:
This was a prospective, cross-sectional study on randomly sampled Chinese children ages 7 to 15 years. Complete ophthalmologic examination was carried out on all participants; anterior-segment parameters and ALs were measured using Fourier-domain optical coherence tomography and automated biometers. Associations between the age, the sex, the refractive error, the iris thickness, the AL, and anterior-chamber depth (ACD) and angle measurements were analyzed using multiple correlation and regression tests. The relationship between the AL and other factors was studied by a linear regression analysis. Only the right eye data were analyzed for statistical purpose.
Results:
A total of 541 children were enrolled in this study. There were no differences in angle parameters between sexes (P>0.05), but boys had a longer AL (P<0.01). The AL increased logarithmically with age in children (P<0.01, R=0.5552, b=6.18). Although the magnitude of myopia also increased with AL, this association was less robust (P<0.05, R=0.0917, b=-0.88). A multiple regression test indicated that the age and the ACD were independently associated with the increase in angle width (b=0.37 to 0.50 and 0.51 to 0.60, respectively; P<0.001).
Conclusions:
All angle measurements increased with age and were positively correlated with the ACD in children 7 to 15 years of age. The AL increased logarithmically with age.
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