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Total Synthesis of Lycopalhine A
Yuji Ochi1, Satoshi Yokoshima1, Tohru Fukuyama1
1Graduate School of Pharmaceutical Sciences, Nagoya University , Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
Organic Letters
|March 8, 2016
Abstract:
The total synthesis of lycopalhine A has been accomplished. The synthesis features construction of the tricyclic system via cleavage of a cyclopropane ring and an ensuing intramolecular Michael addition, stereoselective introduction of a 2-aminoethyl moiety via a reaction of allyltrimethylsilane to a sulfonyliminium ion, and a stereoselective intramolecular aldol reaction.

