Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The molecular chaperone concept.

R J Ellis1, S M van der Vies, S M Hemmingsen

  • 1Department of Biological Sciences, University of Warwick, Coventry, U.K.

Biochemical Society Symposium
|January 1, 1989
PubMed
Summary

Molecular chaperones are essential proteins that guide protein folding and assembly, preventing incorrect structures. They are crucial for various cellular processes, including protein transport and stress recovery.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Management and analysis of high-throughput sequence data for infectious animal diseases.

Revue scientifique et technique (International Office of Epizootics)·2023
Same author

PKR-like ER kinase (PERK) Haplotypes Are Associated with Depressive Symptoms in People with HIV.

Journal of neurology and psychology·2023
Same author

Longitudinal study on the occurrence in pigs of colistin-resistant Escherichia coli carrying mcr-1 following the cessation of use of colistin.

Journal of applied microbiology·2018
Same author

Improving the quality of surgical care: The American College of Surgeons National Surgical Quality Improvement Program.

Revista de calidad asistencial : organo de la Sociedad Espanola de Calidad Asistencial·2017
Same author

First Complete Genomic Sequence of a Rabies Virus from the Republic of Tajikistan Obtained Directly from a Flinders Technology Associates Card.

Genome announcements·2017
Same author

Brain morphometric correlates of metabolic variables in HIV: the CHARTER study.

Journal of neurovirology·2014

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Molecular chaperones are vital proteins involved in protein folding and assembly.
  • Their primary role is to prevent misfolding by shielding exposed hydrophobic or charged surfaces on polypeptide chains.
  • Misfolding can occur during protein synthesis, transport, assembly, and cellular stress.

Purpose of the Study:

  • To provide an overview of the essential functions of molecular chaperones.
  • To discuss the mechanisms by which chaperones prevent protein misfolding.
  • To introduce three major classes of molecular chaperones.

Main Methods:

  • Literature review and synthesis of existing research on molecular chaperones.
  • Categorization of chaperones based on their structure and function.
  • Discussion of the biological contexts in which chaperones operate.

Main Results:

  • Molecular chaperones mediate the correct folding and assembly of proteins into functional structures.
  • They prevent the formation of non-native protein conformations.
  • Three distinct classes of molecular chaperones are identified: nucleoplasmins, BiP group, and chaperonins.

Conclusions:

  • Molecular chaperones are indispensable for maintaining cellular proteostasis.
  • Their function is critical for normal cellular operations and response to stress.
  • Understanding these chaperone classes provides insight into protein quality control mechanisms.

Related Experiment Videos