Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Endocrine System01:29

The Endocrine System

1.9K
The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...
1.9K
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

2.8K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
2.8K
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

333
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
333
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

1.0K
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
1.0K
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

3.9K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
3.9K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

256
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
256

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Probing Strangeness Hadronization with Event-by-Event Production of Multistrange Hadrons.

Physical review letters·2025
Same author

Measurements of Chemical Potentials in Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2024
Same author

Observation of Medium-Induced Yield Enhancement and Acoplanarity Broadening of Low-p_{T} Jets from Measurements in pp and Central Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2024
Same author

Photoproduction of K^{+}K^{-} Pairs in Ultraperipheral Collisions.

Physical review letters·2024
Same author

Emergence of Long-Range Angular Correlations in Low-Multiplicity Proton-Proton Collisions.

Physical review letters·2024
Same author

First Measurement of the |t| Dependence of Incoherent J/ψ Photonuclear Production.

Physical review letters·2024

Related Experiment Video

Updated: Mar 24, 2026

Measurement of Heme Synthesis Levels in Mammalian Cells
09:43

Measurement of Heme Synthesis Levels in Mammalian Cells

Published on: July 9, 2015

12.6K

Endocrine dysfunction in hereditary hemochromatosis.

C Pelusi1, D I Gasparini1, N Bianchi1

  • 1Division of Endocrinology, Department of Medical and Surgical Sciences, University Alma Mater Studiorum, S. Orsola-Malpighi Hospital, Via Massarenti 9, Bologna, Italy.

Journal of Endocrinological Investigation
|March 9, 2016
PubMed
Summary

Hereditary hemochromatosis (HH) is a genetic iron overload disorder. This review details HH-associated endocrine complications like diabetes and hypogonadism, noting their decreased prevalence due to early diagnosis.

Keywords:
DiabetesHereditary hemochromatosisHypogonadismPituitary defects

More Related Videos

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
05:08

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

5.7K
Author Spotlight: Assessing the Impact of Novel Iron Chelators on Cancer Cell Metabolism
05:36

Author Spotlight: Assessing the Impact of Novel Iron Chelators on Cancer Cell Metabolism

Published on: February 23, 2024

1.0K

Related Experiment Videos

Last Updated: Mar 24, 2026

Measurement of Heme Synthesis Levels in Mammalian Cells
09:43

Measurement of Heme Synthesis Levels in Mammalian Cells

Published on: July 9, 2015

12.6K
Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
05:08

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

5.7K
Author Spotlight: Assessing the Impact of Novel Iron Chelators on Cancer Cell Metabolism
05:36

Author Spotlight: Assessing the Impact of Novel Iron Chelators on Cancer Cell Metabolism

Published on: February 23, 2024

1.0K

Area of Science:

  • Endocrinology
  • Genetics
  • Internal Medicine

Background:

  • Hereditary hemochromatosis (HH) is a genetic disorder characterized by excessive iron accumulation.
  • Endocrine complications, particularly diabetes and hypogonadism, are frequently observed in HH patients.
  • Disease presentation is evolving due to increased awareness and early diagnosis.

Purpose of the Study:

  • To review current knowledge on endocrine complications associated with hereditary hemochromatosis.
  • To summarize the pathogenesis and clinical manifestations of HH-related endocrinopathies.
  • To highlight the impact of early diagnosis on the prevalence of these complications.

Main Methods:

  • Literature review of studies on hereditary hemochromatosis and its endocrine manifestations.
  • Analysis of genetic and phenotypic diversity of HH.
  • Synthesis of information on the pathogenesis of diabetes and hypogonadism in HH.

Main Results:

  • Diabetes and hypogonadism are the most common endocrinopathies in HH.
  • Diabetes pathogenesis involves impaired insulin secretion and insulin resistance, potentially exacerbated by obesity and genetics.
  • Hypogonadism is often secondary to pituitary iron deposition affecting gonadotropin secretion.

Conclusions:

  • Endocrine gland dysfunction, while historically common in HH, is increasingly recognized less frequently due to early detection.
  • Understanding the spectrum of HH-associated endocrinopathies remains crucial for comprehensive patient management.
  • Further research is needed to clarify the precise mechanisms and variability of these complications.