Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.6K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
Glaucoma: Overview01:25

Glaucoma: Overview

1.6K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Changes in anterior ocular structures and macula following deep sclerectomy with collagen implant.

European journal of ophthalmology·2017
Same author

Unilateral photorefractive keratectomy for myopic anisometropia improves contrast sensitivity.

Ophthalmology·2004
See all related articles

Related Experiment Video

Updated: Mar 24, 2026

Ultrasound Cyclo Plasty in Eyes with Glaucoma
05:05

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Published on: January 26, 2018

12.8K

Deep sclerectomy in primary open-angle glaucoma and exfoliative glaucoma.

Sakari M A Suominen1, Mika P Harju1, Eija T Vesti2

  • 1Department of Ophthalmology, Helsinki University Central Hospital, Helsinki - Finland.

European Journal of Ophthalmology
|March 9, 2016
PubMed
Summary

Deep sclerectomy effectively lowers intraocular pressure in primary open-angle glaucoma and exfoliative glaucoma. Early postoperative intraocular pressure is a key indicator of surgical success, though reoperations are more frequent in exfoliative glaucoma.

More Related Videos

Iris Fixation via External Pentagram Suturing
05:22

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

2.0K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

2.0K

Related Experiment Videos

Last Updated: Mar 24, 2026

Ultrasound Cyclo Plasty in Eyes with Glaucoma
05:05

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Published on: January 26, 2018

12.8K
Iris Fixation via External Pentagram Suturing
05:22

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

2.0K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

2.0K

Area of Science:

  • Ophthalmology
  • Glaucoma Surgery
  • Surgical Outcomes

Background:

  • Primary open-angle glaucoma (POAG) and exfoliative glaucoma (EXG) are common forms of glaucoma.
  • Effective intraocular pressure (IOP) lowering is crucial for managing glaucoma and preventing vision loss.
  • Deep sclerectomy (DS) is a surgical procedure aimed at reducing IOP.

Purpose of the Study:

  • To evaluate the efficacy of deep sclerectomy (DS) in reducing intraocular pressure (IOP) for patients with primary open-angle glaucoma (POAG) and exfoliative glaucoma (EXG).
  • To identify factors influencing the success of DS surgery in these glaucoma subtypes.

Main Methods:

  • Retrospective analysis of 235 eyes undergoing DS, divided into POAG (127 eyes) and EXG (108 eyes) groups.
  • Primary outcome measured was postoperative IOP reduction.
  • Secondary outcomes included surgical success rates, need for YAG-laser goniopuncture, and postoperative medication requirements. Cox regression analysis was used to identify predictive factors.

Main Results:

  • Both POAG and EXG groups showed statistically significant IOP reduction (p<0.001).
  • Qualified surgical success was achieved in 70% of POAG eyes and 66% of EXG eyes.
  • Reoperations were needed in 12% of POAG eyes and 24% of EXG eyes (p=0.037).
  • Lower IOP at 1 week post-surgery without medication significantly reduced the hazard rate of losing complete and qualified success.

Conclusions:

  • Deep sclerectomy is an effective surgical option for IOP reduction in both POAG and EXG.
  • Early postoperative IOP is a strong predictor of long-term surgical success.
  • Exfoliative glaucoma eyes demonstrated a higher need for reoperation compared to POAG eyes.