Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Timing-dependent synergies between noninvasive motor cortex and spinal cord stimulation in chronic cervical spinal cord injury.

Clinical neurophysiology : official journal of the International Federation of Clinical NeurophysiologyĀ·2025
Same author

Overlapping mechanisms of epidural spinal cord stimulation for pain control and movement recovery.

Current opinion in neurologyĀ·2025
Same author

Hierarchical Bayesian estimation of motor-evoked potential recruitment curves yields accurate and robust estimates.

Brain stimulationĀ·2025
Same author

Electrode position, size, and orientation determine efficacy of cervical epidural stimulation to recruit forelimb muscles in rats.

bioRxiv : the preprint server for biologyĀ·2025
Same author

Transcutaneous Cervical Vagus Nerve Stimulation Improves Speech Comprehension in Noise: A Crossover, Placebo-Controlled Study.

Neuromodulation : journal of the International Neuromodulation SocietyĀ·2025
Same author

Timing-dependent synergies between noninvasive motor cortex and spinal cord stimulation in chronic cervical spinal cord injury.

medRxiv : the preprint server for health sciencesĀ·2025

Related Experiment Video

Updated: Mar 24, 2026

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
08:52

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Published on: July 24, 2019

6.9K

Selective Manipulation of Neural Circuits.

Hong Geun Park1, Jason B Carmel2,3

  • 1Burke Medical Research Institute, White Plains, NY, USA. hop3001@med.cornell.edu.

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics
|March 9, 2016
PubMed
Summary

New genetic tools precisely target neural circuits for function studies. These methods enable specific manipulation of neural circuits, aiding in understanding behavior and repairing connections.

Keywords:
ChemogeneticsCircuit manipulationCircuit specificityGenetic toolsOptogenetics

More Related Videos

Adaptable Angled Stereotactic Approach for Versatile Neuroscience Techniques
06:21

Adaptable Angled Stereotactic Approach for Versatile Neuroscience Techniques

Published on: May 7, 2020

5.8K
A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning
09:22

A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning

Published on: June 22, 2015

15.1K

Related Experiment Videos

Last Updated: Mar 24, 2026

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
08:52

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Published on: July 24, 2019

6.9K
Adaptable Angled Stereotactic Approach for Versatile Neuroscience Techniques
06:21

Adaptable Angled Stereotactic Approach for Versatile Neuroscience Techniques

Published on: May 7, 2020

5.8K
A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning
09:22

A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning

Published on: June 22, 2015

15.1K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Understanding neural circuits requires precise tools for manipulation.
  • Genetic tools offer unprecedented precision in studying neural circuit function.

Purpose of the Study:

  • To describe two general genetic approaches for achieving neural circuit specificity.
  • To review techniques for gain- and loss-of-function manipulations within specific neural circuits.
  • To compare different tools for circuit-specific manipulation and discuss their applications.

Main Methods:

  • Genetic identity: Using cell-specific transcription factors to drive manipulation molecule expression.
  • Spatial connectivity: Combining genetic elements at circuit origin and termination points.
  • Optogenetics and chemogenetics: Introducing light-sensitive or drug-sensitive channels into targeted neurons.

Main Results:

  • Two general genetic strategies achieve circuit specificity: genetic identity and spatial connectivity.
  • These strategies can be combined for enhanced specificity.
  • Optogenetic and chemogenetic tools allow for precise gain- and loss-of-function manipulations.

Conclusions:

  • Developed genetic tools offer precise manipulation of specific neural circuits.
  • These tools are valuable for identifying neural circuits underlying behavior.
  • Potential applications include the repair of neural connections.