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Myocardial Infarction-Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due
Amanda Farage Frade1, Laurie Laugier2, Ludmila Rodrigues Pinto Ferreira3
1Aix-Marseille Université, INSERM, GIMP UMR_S906, 13385, France Laboratory of Immunology Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo Institute for Investigation in Immunology, National Institutes of Science and Technology.
Abstract:
Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as myocardial infarction-associated transcript (MIAT) has been associated with myocardial infarction. Chagas disease causes a severe inflammatory dilated chronic cardiomyopathy (CCC). We investigated the role of MIAT in CCC. A whole-transcriptome analysis of heart biopsy specimens and formalin-fixed, paraffin-embedded samples revealed that MIAT was overexpressed in patients with CCC, compared with subjects with noninflammatory dilated cardiomyopathy and controls. These results were confirmed in a mouse model. Results suggest that MIAT is a specific biomarker of CCC.
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