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B-cell lymphoma with Mott cell differentiation in a cat
Tomomi Kanehara1, Naoko Matsui2, Mami Murakami2,3,4
1Laboratory of Veterinary Pathology, Gifu University, Gifu, Japan.
Veterinary Clinical Pathology
|March 9, 2016
Summary
This study reports the first diagnosed case of B-cell lymphoma with Mott cell differentiation in a cat. This rare feline cancer involves neoplastic lymphoid cells with unique cytoplasmic inclusions.
Area of Science:
- Veterinary Pathology
- Oncology
- Immunohistochemistry
Background:
- B-cell lymphoma is a common malignancy in cats.
- Mott cell differentiation, characterized by cytoplasmic inclusions of immunoglobulin, is rare in feline lymphoid neoplasms.
- This case presents a unique manifestation of feline lymphoma.
Observation:
- A 12-year-old Domestic Shorthair cat presented with anorexia and vomiting.
- Physical examination revealed enlarged tonsils and lymph nodes, and a submucosal epiglottic mass.
- Cytologic and histopathologic examinations showed medium- to large-sized neoplastic lymphoid cells with cytoplasmic inclusions.
Findings:
- Immunohistochemistry confirmed a B-cell immunophenotype (CD20+, Pax5+, MUM1+, CD3-).
- The cytoplasmic inclusions stained positive with Periodic Acid-Schiff (PAS) and contained immunoglobulin M (IgM) and lambda (λ) light chains.
- These inclusions are consistent with aberrant IgM λ light chain accumulation, similar to Russell bodies, leading to a diagnosis of B-cell lymphoma with Mott cell differentiation.
Implications:
- This is the first documented case of feline B-cell lymphoma with Mott cell differentiation.
- Understanding this specific subtype can improve feline lymphoma diagnosis and classification.
- Further research may elucidate the pathogenesis and treatment strategies for this rare condition in cats.
