Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

1.0K
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
1.0K
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

2.4K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.4K
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

829
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
829
Schizophrenia01:17

Schizophrenia

1.6K
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
1.6K
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

997
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
997
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

1.1K
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Value representation in youth psychopathology: evidence of a transdiagnostic risk mechanism for psychosis.

Translational psychiatry·2026
Same author

Computerized assessments of emotional expression and emotional reactivity predict negative symptoms in individuals at clinical high-risk for psychosis.

Psychological medicine·2026
Same author

Contrast sensitivity and subjective visual disturbances across the psychosis continuum.

Cognitive neuropsychiatry·2026
Same author

Impacted and preserved sub-domains of cognitive control in schizophrenia.

Neuropsychologia·2026
Same author

Premorbid adjustment problems, negative symptoms, and cognitive impairment in a large international sample at clinical high risk for psychosis: Findings from the Accelerating Medicines Partnership-Schizophrenia.

Schizophrenia bulletin·2026
Same author

Sound-evoked auditory neurophysiological signals are a window into prodromal functional differences in a preclinical model of Alzheimer's disease.

Scientific reports·2026
Same journal

Prevalence and modulation of rat off-track head scanning on linear tracks: possible implications for representational and dynamic properties of hippocampal place cells.

Neuropsychologia·2026
Same journal

Identifying networks within an fMRI multivariate searchlight analysis.

Neuropsychologia·2026
Same journal

Modulating sentence comprehension in people with aphasia through anodal tDCS: A double-blind randomized cross-over study.

Neuropsychologia·2026
Same journal

Deficient processing of regularity violations during visuospatial neglect: a visual mismatch negativity study.

Neuropsychologia·2026
Same journal

Seeing is believing: mental imagery amplifies moral, emotional, and motivational responding to mentally constructed hypothetical events.

Neuropsychologia·2026
Same journal

Eye Movement Measures of Word-Level and Text-Level Fluency in Disordered Reading: A Comparison of Schizophrenia and Dyslexia.

Neuropsychologia·2026
See all related articles

Related Experiment Video

Updated: Mar 24, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.6K

Schizophrenia: The micro-movements perspective.

Jillian Nguyen1, Ushma Majmudar2, Thomas V Papathomas3

  • 1Graduate Program in Neuroscience, Rutgers University, Piscataway, NJ, USA.

Neuropsychologia
|March 9, 2016
PubMed
Summary
This summary is machine-generated.

Schizophrenia (SZ) patients exhibit altered bodily sensations and motor control. New objective methods reveal slower, noisier movements and impaired deliberate action control in SZ, suggesting sensory-motor integration deficits.

Keywords:
Geometric transformationsMicro-movementsPrecision medicineRDoCSchizophreniaVisuomotor behavior

More Related Videos

Methods to Explore the Influence of Top-down Visual Processes on Motor Behavior
09:49

Methods to Explore the Influence of Top-down Visual Processes on Motor Behavior

Published on: April 16, 2014

27.0K
Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
12:00

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Published on: November 19, 2014

13.4K

Related Experiment Videos

Last Updated: Mar 24, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.6K
Methods to Explore the Influence of Top-down Visual Processes on Motor Behavior
09:49

Methods to Explore the Influence of Top-down Visual Processes on Motor Behavior

Published on: April 16, 2014

27.0K
Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
12:00

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Published on: November 19, 2014

13.4K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Biomedical Engineering

Background:

  • Schizophrenia (SZ) is traditionally viewed as a cognitive and emotional disorder, but it also involves sensory-motor and bodily sensation alterations.
  • Objective methods for quantifying bodily anomalies in SZ are lacking, hindering a comprehensive understanding of the disorder.
  • Altered bodily sensations in SZ may stem from impaired sensory-motor integration and control of actions.

Purpose of the Study:

  • To introduce and validate a novel research method and statistical platform for precise evaluation of peripheral activity in SZ.
  • To objectively characterize visuomotor control and sensory-motor system function in individuals diagnosed with schizophrenia.
  • To identify objective biomarkers for SZ by analyzing micro-movements during goal-directed and spontaneous actions.

Main Methods:

  • Development of new methods for individualized characterization of sensory-motor systems using stochastic signatures of micro-movements.
  • Analysis of velocity- and geometric-transformation-dependent trajectory parameters of hand motions in neurotypical subjects and SZ patients.
  • Comparison of SZ patients' motor performance against empirically determined normative statistical ranges.

Main Results:

  • SZ patients demonstrated significantly slower hand movements with increased noise and randomness compared to controls.
  • Normative signatures of deliberateness were absent in goal-directed reaches of SZ patients but present in spontaneous retractions.
  • Findings suggest impaired sensory-motor integration and an altered balance between deliberate and spontaneous action control in SZ.

Conclusions:

  • The developed objective methods provide precise evaluation of peripheral activity and sensory-motor function in SZ.
  • Altered micro-movement signatures in SZ may serve as objective indicators of avolition, lack of agency, and action ownership.
  • Results support the role of peripheral nervous system contributions to internal models of action control in schizophrenia, aligning with Precision Psychiatry.