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Lactic acid, an important organic acid extensively applied in food, pharmaceutical, and biodegradable polymer industries, is primarily produced via microbial fermentation. This method is favored over chemical synthesis due to its environmental sustainability and capacity for enantiomerically pure product formation. Among various microbial processes, the fermentation of starch-based substrates stands out due to the abundance and renewability of raw materials like corn and potatoes.Hydrolysis of...
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Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Improvement of β-TCP/PLLA biodegradable material by surface modification with stearic acid.

Fengcang Ma1, Sai Chen2, Ping Liu1

  • 1School of Materials Science and Engineering, University of Shanghai for science and technology, Shanghai 200093, China.

Materials Science & Engineering. C, Materials for Biological Applications
|March 9, 2016
PubMed
Summary

Surface modification of beta tricalcium phosphate (β-TCP) with stearic acid improves the compatibility and mechanical strength of poly-L-lactide (PLLA) composites. This enhancement reduces interfacial debonding in the biomaterial.

Keywords:
HydrophilicityInterfacial compatibilityMechanical propertiesSurface modificationTricalcium phosphate

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Materials Engineering

Background:

  • Poly-L-lactide (PLLA) is a widely used biodegradable polymer.
  • Incorporating beta tricalcium phosphate (β-TCP) enhances PLLA's osteoinductive properties.
  • Poor interfacial compatibility between β-TCP and PLLA hinders composite performance.

Purpose of the Study:

  • To improve β-TCP/PLLA biomaterials through surface modification of β-TCP with stearic acid.
  • To investigate the effects of stearic acid surface modification on β-TCP.
  • To evaluate the impact of modification on the mechanical properties and interfacial behavior of β-TCP/PLLA composites.

Main Methods:

  • Surface modification of β-TCP using stearic acid.
  • Characterization of modified β-TCP using FTIR, XPS, TGA, and CA.
  • Fabrication and mechanical testing (bending, tensile) of β-TCP/PLLA composites.
  • Microstructural analysis of composite fractures using SEM.

Main Results:

  • Stearic acid reacted with β-TCP, forming oxhydryl groups on the surface.
  • Surface modification significantly improved the bending and tensile strengths of β-TCP/PLLA composites.
  • SEM analysis revealed decreased interfacial debonding between β-TCP and PLLA after modification.

Conclusions:

  • Stearic acid surface modification is an effective strategy to enhance the interfacial compatibility and mechanical properties of β-TCP/PLLA biomaterials.
  • Improved interfacial adhesion leads to better load transfer and reduced failure at the filler-matrix interface.
  • The modified composites show potential for improved performance in biomedical applications.