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Influencing negative symptoms of schizophrenia with repetitive transcranial magnetic stimulation: a case study
Radovan Prikryl1, Simona Skotakova1, Tomas Kasparek1
11Department of Psychiatry, Masaryk University, Faculty of Medicine and Faculty Hospital Brno, Brno, Czech Republic.
Background:
The present trial was designed to investigate the influence of repetitive transcranial magnetic stimulation (rTMS) on negative schizophrenic symptoms using high-frequency stimulation of the left dorsolateral prefrontal cortex in a simple blind randomized design.
Methods:
The study was carried out on a 42-year-old patient with schizophrenia (paranoid subtype) with prominent negative symptoms who was first treated with sham rTMS during the first 3 weeks and then with real high frequency during the following 3 weeks. He was rated before and after the sham and after the real rTMS therapy for positive, negative and depressive symptoms.
Results:
rTMS was superior to sham treatment in reduction of negative and depressive symptoms.
Conclusion:
High-frequency rTMS applied over the left dorsolateral prefrontal cortex led to a reduction of severity of negative symptoms in a patient with chronic schizophrenia and may be beneficial as an augmentation option to antipsychotics in the treatment of negative symptoms of schizophrenia.
