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Updated: Mar 24, 2026

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Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders

Camilla Evangelisti1,2, Vittoria Cenni1,2, Giovanna Lattanzi3,4

  • 1CNR Institute for Molecular Genetics, Unit of Bologna, Bologna, Italy.

British Journal of Clinical Pharmacology
|March 9, 2016
PubMed

Insights

The mammalian target of rapamycin (mTOR) pathway regulates cell functions and lifespan. Inhibiting mTOR with rapamycin shows potential for anti-aging therapies and treating age-related diseases.

Area of Science:

  • Cellular Biology
  • Biochemistry
  • Gerontology

Background:

  • The mammalian target of rapamycin (mTOR) pathway is a crucial regulator of fundamental cellular processes including growth, survival, metabolism, and autophagy.
  • Rapamycin, an mTOR inhibitor, has demonstrated lifespan extension in various animal models.
  • Rapamycin has also shown efficacy in ameliorating cellular phenotypes associated with aging and progeroid syndromes like Hutchinson-Gilford Progeria syndrome (HGPS).

Purpose of the Study:

  • To review the current understanding of mTOR signaling.
  • To explore the potential of mTOR inhibitors in combating age-associated diseases.
  • To discuss the implications of mTOR inhibition for increasing longevity.

Main Methods:

  • Literature review of studies on mTOR signaling.
  • Analysis of research on rapamycin's effects on lifespan and aging phenotypes.
  • Synthesis of findings related to mTOR inhibitors and age-related diseases.

Main Results:

  • mTOR pathway is integral to cellular homeostasis and aging.
  • Rapamycin treatment extends lifespan across diverse species.
  • mTOR inhibition can reverse aging-related cellular dysfunction.

Conclusions:

  • Understanding mTOR signaling is critical for developing interventions against aging.
  • mTOR inhibitors represent a promising therapeutic strategy for age-related diseases.
  • Targeting mTOR may offer a pathway to enhance human longevity.
Keywords:
Hutchinson-Gilford Progeria syndrome (HGPS)ageinglamin AmTOR inhibitorsprogeria-related diseasesrapamycin

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