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Radiosynthesis of 1-2-[18F]Fluoroethyl-L-Tryptophan using a One-pot, Two-step Protocol
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Recurring déjà vu associated with 5-hydroxytryptophan.
Seema Kalra1, Andrew Chancellor2, Adam Zeman3
11Department of Neurology, Newcastle General Hospital, Newcastle, UK.
Acta Neuropsychiatrica
|March 9, 2016
Summary
This study details a case where 5-hydroxytryptophan triggered prolonged déjà vu. This finding suggests the serotonergic system plays a role in the neuropharmacology of déjà vu experiences.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Déjà vu is a common phenomenon and a symptom in neuropsychiatric disorders.
- The underlying mechanisms of déjà vu are not fully understood.
- This study presents a unique iatrogenic case relevant to déjà vu's neuropharmacology.
Purpose of the Study:
- To investigate the neuropharmacological basis of déjà vu.
- To report an iatrogenic case of intense, protracted déjà vu.
- To explore the role of the serotonergic system in déjà vu.
Main Methods:
- A case presentation of a 42-year-old woman treated with 5-hydroxytryptophan and carbidopa.
- Observation of intense and prolonged déjà vu episodes following treatment.
- Discussion of the case in the context of neuroanatomy and neuropharmacology.
Main Results:
- The patient experienced significant déjà vu after receiving 5-hydroxytryptophan and carbidopa.
- The déjà vu episodes were intense and lasted for several hours.
- The case provides insights into the neuropharmacological triggers of déjà vu.
Conclusions:
- The serotonergic system is implicated in the generation of déjà vu.
- Pharmacological agents affecting serotonin may influence déjà vu experiences.
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