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Effects of pancreastatin on insulin and pancreatic polypeptide secretion in the dog
1Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
Endocrinologia Japonica
|October 1, 1989
Abstract:
Porcine pancreastatin (1.19 nmol) was administered into the peripheral vein (i.v.) or the third cerebral ventricle (i.t.v.) of dogs and its effect on the secretion of insulin and pancreatic polypeptide (PP) studied. Neither means of administration had any effect on basal and glucose-induced insulin or PP secretion. However, i.v. pancreastatin did inhibit the i.v. CCK-8-induced insulin but not PP release. Pancreastatin may thus play a role in the regulation of insulin secretion in the canine pancreas.