Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathogenesis of pterygium.

J C Hill1, R Maske

  • 1Department of Ophthalmology, Groote Schuur Hospital, Cape Town, South Africa.

Eye (London, England)
|January 1, 1989
PubMed
Summary

Chronic inflammation, not just UV radiation, is key in pterygium development. Histological analysis reveals T-cell infiltration, suggesting irritation triggers a repair response leading to pterygium growth.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum: Centrality-Dependent Modification of Jet-Production Rates in Deuteron-Gold Collisions at sqrt[s_{NN}]=200  GeV [Phys. Rev. Lett. 116, 122301 (2016)].

Physical review letters·2025
Same author

Quality indicators for the community care of MSK conditions: An online modified-Delphi study.

Musculoskeletal science & practice·2025
Same author

Optimising physiotherapy for people with lateral elbow tendinopathy - Results of a mixed-methods pilot and feasibility randomised controlled trial (OPTimisE).

Musculoskeletal science & practice·2024
Same author

Measurement of Direct-Photon Cross Section and Double-Helicity Asymmetry at sqrt[s]=510  GeV in p[over →]+p[over →] Collisions.

Physical review letters·2023
Same author

Comparing an optimised physiotherapy treatment package with usual physiotherapy care for people with tennis elbow - protocol for the OPTimisE pilot and feasibility randomised controlled trial.

Pilot and feasibility studies·2022
Same author

Using tranexamic acid for an additional 24 hours postoperatively in hip and knee arthroplasty saves money: a cost analysis from the TRAC-24 randomized control trial.

Bone & joint open·2022

Area of Science:

  • Ophthalmology
  • Pathology
  • Epidemiology

Background:

  • Pterygium pathogenesis is debated, with theories involving ultraviolet (UV) radiation and chronic inflammation.
  • Epidemiological links between pterygium and other actinic disorders are not consistently observed.
  • Distinct vascularity in pterygia suggests a unique inflammatory component.

Purpose of the Study:

  • To review histological and epidemiological data on pterygium.
  • To investigate the role of chronic inflammation versus UV radiation in pterygium development.
  • To differentiate pterygium from related ocular surface disorders.

Main Methods:

  • Review of histological findings from excised pterygia.
  • Analysis of epidemiological survey data from Southern Africa.
  • Comparison of pterygium characteristics with actinic disorders like pinguecula and climatic droplet keratopathy.

Main Results:

  • Pterygium is not strongly associated with other chronic actinic disorders.
  • Excised pterygia exhibit lymphocytic infiltration, predominantly T cells.
  • Vascularity in pterygia appears linked to chronic inflammation.

Conclusions:

  • Chronic irritation, regardless of the cause, initiates inflammatory processes in pterygium.
  • Inflammatory edema, repair attempts, and angiogenesis contribute to pterygium formation.
  • Both chronic inflammation and actinic damage drive the fibrovascular response in growing pterygia.

Related Experiment Videos