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Related Experiment Video

Updated: Mar 24, 2026

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment
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Canine lymphoma: a review.

M Zandvliet1

  • 1a Faculty of Veterinary Medicine, Department of Clinical Sciences of Companion Animals , Utrecht University , Yalelaan , Utrecht , The Netherlands.

The Veterinary Quarterly
|March 9, 2016
PubMed
Summary

Canine lymphoma (cL) is a common cancer in dogs, often presenting as generalized lymphadenopathy. While chemotherapy offers remission, drug resistance is common, highlighting the need for new treatments.

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British journal of cancer·2025
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Modeling potential masking of echolocating sperm whales exposed to continuous 1-2 kHz naval sonar.

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A longitudinal study of ABC transporter expression in canine multicentric lymphoma.

Veterinary journal (London, England : 1997)·2014
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Multi-drug resistance in a canine lymphoid cell line due to increased P-glycoprotein expression, a potential model for drug-resistant canine lymphoma.

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Prednisolone inclusion in a first-line multidrug cytostatic protocol for the treatment of canine lymphoma does not affect therapy results.

Veterinary journal (London, England : 1997)·2013

Area of Science:

  • Veterinary Oncology
  • Comparative Oncology
  • Canine Cancer Research

Background:

  • Canine lymphoma (cL) is a prevalent neoplasia in dogs, mirroring human non-Hodgkin lymphoma.
  • Environmental and genetic factors are implicated, though the exact cause remains elusive.
  • cL exhibits diverse clinical and histological presentations, with multicentric lymphoma being most common.

Purpose of the Study:

  • To review current knowledge on canine lymphoma.
  • To update recent literature on cL diagnosis, treatment, and prognosis.
  • To highlight challenges and future directions in managing canine lymphoma.

Main Methods:

  • Literature review of canine lymphoma.
  • Analysis of clinical presentations and histological subtypes.
  • Summary of current treatment protocols and prognostic factors.

Main Results:

  • Most dogs present with multicentric lymphoma, often B-cell origin.
  • Chemotherapy, typically doxorubicin-based, achieves remission in most dogs (median survival 10-14 months).
  • Drug resistance, linked to ABC transporters, is a major challenge, necessitating novel therapeutic strategies.

Conclusions:

  • Canine lymphoma management requires understanding prognostic factors like stage and immunophenotype.
  • Addressing drug resistance is crucial for improving outcomes.
  • Emerging therapies like immunotherapy and targeted therapy hold promise for future canine lymphoma treatment.
Keywords:
Dogcaninelymphomanon-Hodgkinreview

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