Related Experiment Video
Updated: Mar 24, 2026

Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin
Published on: July 14, 2017
Mathematical model for calcium-assisted epidermal homeostasis
Yasuaki Kobayashi1, Yusuke Sawabu2, Hiroyuki Kitahata3
1Research Institute for Electronic Science, Hokkaido University, N12W7, Kita-ku, Sapporo 060-0812, Japan; CREST, Japan Science and Technology Agency, Gobancho, Chiyoda-ku, Tokyo 102-0076, Japan.
Calcium dynamics beneath the stratum corneum maintain epidermal homeostasis. This mathematical model shows faster skin barrier recovery with air exposure, dependent on disruption size.
Area of Science:
- Dermatology
- Biophysics
- Mathematical Biology
Background:
- Epidermal homeostasis is crucial for skin barrier function.
- Calcium signaling plays a role in regulating epidermal structure and repair.
Purpose of the Study:
- To propose a mechanism for epidermal homeostasis mediated by calcium dynamics.
- To investigate the influence of calcium dynamics on epidermal structure and barrier repair using a mathematical model.
Main Methods:
- Development of a mathematical model of the epidermis.
- Simulations of calcium dynamics beneath the stratum corneum.
- Modeling of epidermal barrier disruption and recovery.
Main Results:
- Calcium dynamics effectively reduce spatio-temporal fluctuations in the epidermis.
- The model accurately reproduces experimental findings of accelerated barrier recovery upon air exposure.
- Simulation results demonstrate a correlation between barrier disruption size and recovery speed.
Conclusions:
- Calcium signaling is a key regulator of epidermal homeostasis and barrier repair.
- Mathematical modeling provides insights into the biophysical mechanisms underlying skin recovery.
- The size of skin barrier disruption significantly impacts the rate of healing.
More Related Videos
10:46Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
Published on: July 16, 2013
10:05Measurement of Calcium Fluctuations Within the Sarcoplasmic Reticulum of Cultured Smooth Muscle Cells Using FRET-based Confocal Imaging
Published on: June 20, 2016
Related Concept Videos
Feedback Regulation of Calcium Concentration
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Skeleton and Calcium Homeostasis
Calmodulin-dependent Signaling
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
Synthesis and Functions of Calcitonin
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
Renewal of Skin Epidermal Stem Cells
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...