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Peripheral neuropathy in diabetic monkeys.

D R Cornblath1, M A Hillman, J S Striffler

  • 1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Diabetes
|November 1, 1989
PubMed
Summary
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Spontaneously diabetic monkeys develop peripheral neuropathy, similar to humans. These nerve conduction abnormalities in diabetic primates appear early after hyperglycemia onset, suggesting their utility as a model for human diabetic neuropathy.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Primate Models

Background:

  • Diabetic peripheral neuropathy is a common complication in humans, causing significant morbidity.
  • Understanding its pathogenesis requires appropriate experimental models.

Purpose of the Study:

  • To investigate if spontaneously diabetic obese adult rhesus monkeys develop peripheral neuropathy.
  • To determine if neuropathy onset is early or late relative to hyperglycemia.

Main Methods:

  • Nerve conduction studies (motor and sensory) were performed on 13 adult male rhesus monkeys (4 diabetic, 9 non-diabetic).
  • Evaluated peroneal, median, and ulnar nerves for conduction velocities, F-wave latencies, and evoked amplitudes.

Main Results:

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  • Diabetic monkeys exhibited significantly reduced motor conduction velocities and prolonged F-wave latencies.
  • Increased motor nerve conduction times were observed in diabetic monkeys, detectable as early as 2 years post-hyperglycemia onset.
  • No significant difference was found in motor-evoked amplitudes between groups.

    • Conclusions:

    • Spontaneously diabetic rhesus monkeys display peripheral nerve abnormalities analogous to human diabetic neuropathy.
    • These findings support the use of this primate model for studying human diabetic neuropathy pathogenesis and therapeutics.