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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Cell-mediated Immune Responses01:40

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Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
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Immunization practices in solid organ transplant recipients.

Isao Miyairi1, Takanori Funaki1, Akihiko Saitoh2

  • 1Division of Pediatric Infectious Diseases, National Center for Child Health and Development, Tokyo, Japan.

Vaccine
|March 9, 2016
PubMed
Summary
This summary is machine-generated.

Vaccine-preventable diseases pose risks for transplant recipients. Prioritizing live attenuated vaccines before transplantation and considering simultaneous or post-transplant vaccination when immunosuppression is minimal can improve patient immunity.

Keywords:
ImmunosuppressionInactivated vaccineLive attenuated vaccineSolid organ transplantation

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Area of Science:

  • Immunology
  • Transplantation Medicine
  • Vaccinology

Background:

  • Solid organ transplant recipients require immunosuppression, increasing vulnerability to vaccine-preventable diseases.
  • Pre-transplant vaccination is ideal but often limited by time, necessitating strategic vaccine administration.

Purpose of the Study:

  • To review vaccination strategies for solid organ transplant recipients.
  • To evaluate the safety and efficacy of live attenuated and inactivated vaccines in this population.

Main Methods:

  • Literature review of studies on vaccine administration in transplant recipients.
  • Analysis of evidence regarding pre-transplant, simultaneous, and post-transplant vaccination.

Main Results:

  • Live attenuated vaccines should be prioritized if pre-transplant time is limited.
  • Inactivated vaccines appear safe and effective post-transplant.
  • Live attenuated vaccines may be safe and effective under minimal immunosuppression.

Conclusions:

  • Strategic vaccine administration, including prioritization and timing, is crucial for transplant recipients.
  • Further research is needed on serologic monitoring and booster immunizations.