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Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

9.7K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Related Experiment Video

Updated: Mar 24, 2026

Isolation and Analysis of Hematopoietic Stem Cells from the Placenta
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Isolation and Analysis of Hematopoietic Stem Cells from the Placenta

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Tracking HSC Origin: From Bench to Placenta.

Vincenzo Calvanese1, Hanna K A Mikkola2

  • 1Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90095, USA.

Developmental Cell
|March 9, 2016
PubMed
Summary
This summary is machine-generated.

Researchers identified specific hemogenic precursor cells in mouse embryos and placentas. These cells, similar to those reprogrammed in vitro, can mature into transplantable hematopoietic stem cells (HSCs).

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Related Experiment Videos

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Area of Science:

  • Developmental biology
  • Stem cell research
  • Hematopoiesis

Background:

  • Understanding hematopoietic stem cell (HSC) development is crucial for regenerative medicine.
  • In vitro lineage reprogramming offers insights into cell differentiation pathways.

Purpose of the Study:

  • To investigate the in vivo origins of hematopoietic stem cells.
  • To connect in vitro reprogramming findings with in vivo developmental processes.

Main Methods:

  • Analysis of mouse placenta and embryo tissues.
  • Identification of specific cell surface markers (Prom1, Sca1, CD34, CD45).
  • In vitro cell culture and transplantation assays.

Main Results:

  • Discovery of Prom1(+)Sca1(+)CD34(+)CD45(-) hemogenic precursors in vivo.
  • These precursors resemble fibroblast-derived hemato-vascular precursors generated in vitro.
  • The identified precursors successfully mature into transplantable HSCs in culture.

Conclusions:

  • In vitro reprogramming models accurately reflect in vivo hematopoietic stem cell development.
  • Specific hemogenic precursors in the embryo and placenta are key to HSC formation.
  • These findings advance our understanding of HSC origins and potential therapeutic applications.