Tracking HSC Origin: From Bench to Placenta

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Isolation and Analysis of Hematopoietic Stem Cells from the Placenta
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Published on: June 24, 2008

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Vincenzo Calvanese1, Hanna K A Mikkola2

  • 1Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90095, USA.

Developmental Cell
|March 9, 2016
PubMed

Reporting in Developmental Cell, Pereira et al. (2016) use in vitro lineage reprogramming insights to inform understanding of hematopoietic stem cell (HSC) development in vivo. They find Prom1(+)Sca1(+)CD34(+)CD45(-) hemogenic precursors, akin to fibroblast-derived hemato-vascular precursors, in mouse placenta and embryo. The cells mature into transplantable HSCs in culture.

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