Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

2.4K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.4K
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

997
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
997
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

829
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
829

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantitative trait loci mapping of gene expression and chromatin accessibility in primary fibroblasts reveals shared allelic effects between Latin American and European ancestries.

BMC genomics·2026
Same author

Association of Fetal Gene Regulatory Gene Deletions With Poor Cognition in Schizophrenia and Community-Based Samples.

The American journal of psychiatry·2026
Same author

Exploring Group Differences in Attenuated Symptoms and Functioning Between Clinical High-Risk Individuals With and Without Posttraumatic Stress Disorder.

Early intervention in psychiatry·2026
Same author

Cannabis and tobacco co-use predicts psychosis in clinical high risk cohorts.

Nature. Mental health·2026
Same author

Symptom Dimension-Specific Neurotransmitter Correlates of Psychopathology and Cognition in Early Psychosis.

bioRxiv : the preprint server for biology·2026
Same author

Age-varying associations between parent-reported executive function and internalizing/externalizing problems in children with neurofibromatosis type 1: an integrative analysis of data from nine institutions.

Journal of the International Neuropsychological Society : JINS·2026
Same journal

A Student-Faculty Collaboration: Embedding Trauma-Informed Care in Medical Education.

Harvard review of psychiatry·2026
Same journal

Inpatient Management of Benzodiazepine Withdrawal: A Narrative Review of a Systematic, Individualized Taper Design.

Harvard review of psychiatry·2026
Same journal

Application of mHealth Approaches to Increase Access to and Engagement of Mental Health Treatment Among Underserved Communities.

Harvard review of psychiatry·2026
Same journal

Integrating Climate Change and Mental Health into Medical Education: A Narrative Review of Interventions and Assessment Tools.

Harvard review of psychiatry·2026
Same journal

The Long Road Back: An Integrative and Interdisciplinary Approach to Care After Traumatic Brain Injury.

Harvard review of psychiatry·2026
Same journal

Poverty, Policy, and Mental Health Inequities: Evidence, Challenges, and Opportunities.

Harvard review of psychiatry·2026
See all related articles

Related Experiment Video

Updated: Mar 24, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
13:08

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

9.5K

Electrophysiological Endophenotypes for Schizophrenia.

Emily M Owens1, Peter Bachman, David C Glahn

  • 1From the Semel Institute for Neuroscience and Human Behavior, and Department of Psychology, University of California Los Angeles (Ms. Owens and Dr. Bearden); Department of Psychiatry, University of Pittsburgh (Dr. Bachman); Department of Psychiatry, Yale University School of Medicine, and Olin Neuropsychiatric Research Center, Institute of Living, Hartford, CT (Dr. Glahn).

Harvard Review of Psychiatry
|March 9, 2016
PubMed
Summary
This summary is machine-generated.

Electrophysiological endophenotypes offer a mechanistic view into schizophrenia by examining heritable traits. Research highlights disrupted brain signaling, suggesting key pathways for future genetic and neurobiological studies.

More Related Videos

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
12:00

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Published on: November 19, 2014

13.4K
Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

4.8K

Related Experiment Videos

Last Updated: Mar 24, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
13:08

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

9.5K
Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
12:00

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Published on: November 19, 2014

13.4K
Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

4.8K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Schizophrenia is a complex brain disorder with unclear pathophysiologic mechanisms.
  • Endophenotypes, or measurable heritable traits, are crucial for understanding complex diseases.
  • Electrophysiological endophenotypes provide a mechanistic lens for schizophrenia research.

Purpose of the Study:

  • To review electrophysiological endophenotypes as tools for understanding schizophrenia.
  • To detail experimental procedures, reliability, heritability, and genetic/neurobiological associations of these endophenotypes.
  • To synthesize evidence implicating neurotransmitter imbalances in schizophrenia's pathophysiology.

Main Methods:

  • Literature review of electrophysiological endophenotypes in schizophrenia research.
  • Analysis of experimental procedures, reliability, and heritability data.
  • Examination of genetic and neurobiological associations, including EEG findings.

Main Results:

  • Electrophysiological endophenotypes show promise in elucidating schizophrenia mechanisms.
  • Evidence suggests a disrupted balance of glutamatergic signaling and GABAergic inhibition.
  • Genetic architecture of specific endophenotypes is increasingly understood.

Conclusions:

  • Refining electrophysiological endophenotype measurement is vital.
  • Expanding genetic association studies is a critical next step.
  • Integrating diverse datasets will advance understanding of schizophrenia's genetic-phenotype link.