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Serum NT-proBNP Levels Are Not Related to Vitamin D Status in Young Patients with Congenital Heart Defects

E Passeri1, R Rigolini2, E Costa2

  • 1Endocrinology Unit, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.

Disease Markers
|March 9, 2016
PubMed

Insights

Vitamin D deficiency is common in children with congenital heart defects (CHD). This study found no link between low vitamin D levels and cardiac strain marker NT-proBNP in these young patients.

Area of Science:

  • Pediatric Cardiology
  • Endocrinology
  • Nutritional Science

Background:

  • Vitamin D deficiency is prevalent in children and increases with age.
  • Vitamin D influences cardiac function and NT-proBNP release in adults with heart failure.

Purpose of the Study:

  • To determine vitamin D status in young patients with congenital heart defects (CHD).
  • To investigate the association between hypovitaminosis D and NT-proBNP levels in pediatric CHD patients.

Main Methods:

  • Cross-sectional study of 230 young patients with CHD.
  • Assessed serum 25-hydroxyvitamin D (25OHD), parathyroid hormone (PTH), and NT-proBNP levels.
  • Analyzed correlations between vitamin D status, PTH, and NT-proBNP.

Main Results:

  • 55.3% of patients had vitamin D deficiency (25OHD <20 ng/mL).
  • Vitamin D levels correlated inversely with age and height SDS.
  • No significant correlation was found between NT-proBNP levels and 25OHD or PTH levels.

Conclusions:

  • Vitamin D deficiency and hyperparathyroidism are common in young patients with CHD.
  • Hypovitaminosis D and hyperparathyroidism are not associated with elevated NT-proBNP levels in this population.
Abstract

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