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Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis
Published on: February 24, 2023
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Musculoskeletal melioidosis: An under-diagnosed entity in developing countries
Hitendra G Patil1, Manit Gundavda1, Vivek Shetty1
1Department of Orthopaedics, Hinduja Hospital and MRC, Mahim, India.
Journal of Orthopaedics
|March 9, 2016
Summary
Melioidosis, a bacterial infection, can affect bones and muscles. Early diagnosis and specific antibiotics like ceftazidime are crucial for treating this potentially fatal disease.
Area of Science:
- Infectious Diseases
- Microbiology
- Public Health
Background:
- Melioidosis is an infectious disease caused by Burkholderia pseudomallei, a Gram-negative bacterium found in soil.
- Musculoskeletal melioidosis, while not common, presents a diagnostic challenge.
Purpose of the Study:
- To report cases of musculoskeletal melioidosis.
- To highlight the importance of diagnosing melioidosis due to its high mortality rate in septicemic form.
Main Methods:
- Retrospective case series of three patients with musculoskeletal melioidosis.
- Clinical presentation and treatment outcomes were analyzed.
Main Results:
- One patient died from septicemic acute respiratory distress syndrome (ARDS).
- Two patients fully recovered with no recurrences after a minimum 6-month follow-up.
- The study identified new cases in Karnataka, Goa, and Southern Maharashtra, India.
Conclusions:
- Musculoskeletal melioidosis requires prompt diagnosis and specific antibiotic treatment.
- Intravenous ceftazidime and trimethoprim-sulfamethoxazole are effective treatments.
- The septicemic form of melioidosis has a mortality rate exceeding 90%.
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