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Updated: Mar 24, 2026

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

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Delayed Posthypoxic Leukoencephalopathy: Improvement with Antioxidant Therapy.

Franklin King¹, Nicholas A Morris², Jeremy D Schmahmann³

¹Department of Psychiatry, Massachusetts General Hospital and McLean Hospital, Boston, Mass., USA.

Case Reports in Neurology

|March 9, 2016

Summary

Delayed posthypoxic leukoencephalopathy (DPHL) may follow opiate overdose. Antioxidant therapy showed a potential therapeutic effect in a patient with DPHL, warranting further investigation.

Keywords:

Anoxia Antioxidants Delayed posthypoxic leukoencephalopathy Hypoxia Leukoencephalopathy Overdose

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Last Updated: Mar 24, 2026

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

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Published on: May 4, 2015

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Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy

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Published on: October 28, 2022

Area of Science:

Neurology
Toxicology
Biochemistry

Background:

Delayed posthypoxic leukoencephalopathy (DPHL) is a rare neurological condition.
Its pathophysiology, often linked to hypoxic insults like opiate overdose, remains unclear.

Observation:

A 63-year-old male presented with altered mental status 10 days post-opiate overdose and aspiration pneumonia.
Clinical and imaging findings were characteristic of DPHL.

Findings:

Antioxidant therapy, including vitamins E, C, B-complex, and coenzyme Q10, was initiated.
The patient experienced a prompt reversal of clinical deterioration following antioxidant treatment.

Implications:

This case suggests a potential therapeutic role for antioxidants in managing DPHL.
Findings support the hypothesis that reactive oxygen species contribute to DPHL pathophysiology.