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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Cancer Stem Cells and Tumor Maintenance02:40

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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Related Experiment Video

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Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
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Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

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Breast cancer stem cells programs: enter the (non)-code.

Marion A Salvador, Daniel Birnbaum, Emmanuelle Charafe-Jauffret

    Briefings in Functional Genomics
    |March 10, 2016
    PubMed
    Summary

    Cancer stem cells (CSCs) drive breast tumor growth, heterogeneity, and therapy resistance. Targeting noncoding RNAs regulating CSCs offers new therapeutic strategies to improve patient survival.

    Keywords:
    RNAbreastcancercancer stem cellepigeneticslongmicroRNAnoncoding

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    Mammosphere Formation Assay from Human Breast Cancer Tissues and Cell Lines
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    Mammosphere Formation Assay from Human Breast Cancer Tissues and Cell Lines

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    Area of Science:

    • Oncology
    • Molecular Biology
    • Genetics

    Background:

    • Breast tumors possess a hierarchical structure driven by cancer stem cells (CSCs).
    • CSCs are responsible for tumor heterogeneity, therapeutic resistance, and relapse.
    • Noncoding RNAs (ncRNAs) regulate cell identity and are dysregulated in breast CSCs.

    Purpose of the Study:

    • To review the role of ncRNAs in breast CSC biology.
    • To explore ncRNAs in breast cancer initiation, maintenance, therapeutic resistance, and metastasis.
    • To discuss the clinical potential of ncRNAs as biomarkers or therapies.

    Main Methods:

    • Literature review focusing on noncoding RNAs (microRNAs and long noncoding RNAs).
    • Analysis of molecular mechanisms underlying CSC stemness.
    • Evaluation of therapeutic strategies targeting ncRNAs in breast cancer.

    Main Results:

    • Noncoding RNAs are critical regulators of breast CSC self-renewal and differentiation.
    • Dysregulated ncRNAs contribute to therapeutic resistance and metastatic potential of CSCs.
    • Specific ncRNAs are implicated in various stages of breast cancer progression.

    Conclusions:

    • Targeting ncRNAs involved in CSC regulation presents a promising therapeutic avenue.
    • Noncoding RNAs hold potential as biomarkers for early detection and prognosis.
    • Further research into ncRNA-mediated pathways can lead to improved breast cancer treatments.