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Updated: Mar 24, 2026

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
Published on: December 9, 2010
Detection of Sulfatase Enzyme Activity with a CatalyCEST MRI Contrast Agent
Sanhita Sinharay1, Gabriela Fernández-Cuervo2, Jasmine P Acfalle1
1Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, USA.
Abstract:
A chemical exchange saturation transfer (CEST) MRI contrast agent has been developed that detects sulfatase enzyme activity. The agent produces a CEST signal at δ=5.0 ppm before enzyme activity, and a second CEST signal appears at δ=9.0 ppm after the enzyme cleaves a sulfate group from the agent. The comparison of the two signals improved detection of sulfatase activity.
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