[Antigen recognition and signal transduction in T lymphocytes]

Stopped-flow fluorometry gave a unique opportunity to observe a direct cellular interaction between functionally different subsets of lymphocytes in vitro. By this method the molecular mechanism of receptor-mediated recognition and signaling in T lymphocytes (T cells) has been well analyzed. The method is further in progress to observe calcium signals in a single T lymphocyte by using a digital imaging fluorescence microscope.