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Related Concept Videos

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Related Experiment Video

Updated: Mar 24, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
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Pigmented desmoplastic trichilemmoma.

Carolina Martínez-Ciarpaglini1, Carlos Monteagudo1

  • 1Department of pathology, Hospital Clínico Universitario, University of Valencia, Valencia, Spain.

Journal of Cutaneous Pathology
|March 10, 2016
PubMed
Summary
This summary is machine-generated.

A rare pigmented variant of desmoplastic trichilemmoma (DT), a pseudomalignant skin lesion, has been identified. This finding is crucial for distinguishing it from malignant pigmented tumors like basal cell carcinoma (BCC).

Keywords:
desmoplastic trichilemmomaouter root sheathpigmented skin tumors

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Area of Science:

  • Dermatopathology
  • Oncology

Background:

  • Desmoplastic trichilemmoma (DT) is a pseudomalignant variant of trichilemmoma, characterized by specific cellular and structural features.
  • DT typically presents with a lobular growth pattern, glycogen-rich cells, peripheral nuclear palisading, and a thickened basement membrane.
  • A central hyalinized area with epithelial cords and strands can mimic invasive carcinoma.

Observation:

  • This report details a case of desmoplastic trichilemmoma with an unusual and extensive melanocytic cell component.
  • The case also exhibits prominent melanin deposition within the lesion.
  • This represents a previously unreported pigmented variant of desmoplastic trichilemmoma.

Findings:

  • The presented case fulfills the diagnostic criteria for desmoplastic trichilemmoma.
  • The presence of significant melanocytic infiltration and melanin deposition distinguishes this case from conventional DT.
  • This pigmented variant necessitates careful consideration in differential diagnoses.

Implications:

  • Recognition of this pigmented variant is essential for accurate diagnosis.
  • It aids in differentiating desmoplastic trichilemmoma from malignant pigmented tumors, particularly pigmented basal cell carcinoma (BCC).
  • This expands the spectrum of presentations for desmoplastic trichilemmoma and informs diagnostic approaches.