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Left ventricular systolic function in Nigerian children infected with HIV/AIDS: a cross-sectional study

Ijeoma Arodiwe1, Anthony Ikefuna2, Egbuna Obidike2

  • 1Department of Paediatrics, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria. arodiwenephrol@yahoo.com.

Cardiovascular Journal of Africa
|March 10, 2016
PubMed

Insights

Left ventricular systolic dysfunction is prevalent in Nigerian children with HIV/AIDS, affecting 27% of those with HIV and 81.2% with AIDS. Lower CD4 counts and older age predict this cardiac complication.

Area of Science:

  • Pediatric Cardiology
  • Infectious Diseases
  • Echocardiography

Background:

  • Cardiac complications are a major cause of illness and death in children with HIV/AIDS.
  • These complications are under-reported in sub-Saharan Africa.

Purpose of the Study:

  • To assess ventricular systolic function in Nigerian children with HIV/AIDS using Doppler echocardiography.
  • To determine the prevalence and predictors of left ventricular systolic dysfunction in this population.

Main Methods:

  • Observational, cross-sectional Doppler echocardiographic study.
  • Evaluated ventricular systolic function in children diagnosed with HIV/AIDS at a tertiary clinic.

Main Results:

  • Left ventricular systolic dysfunction was found in 27.0% of children with HIV and 81.2% with AIDS.
  • The AIDS group showed significantly lower mean fractional shortening (31.6 ± 9.5%) compared to the HIV group (35.3 ± 10.5%, p = 0.001).
  • CD4(+) cell count and age were significant predictors (p = 0.038 and p = 0.025, respectively).

Conclusions:

  • Left ventricular systolic dysfunction is a common finding in Nigerian children with HIV/AIDS.
  • The study highlights the need for cardiac monitoring in pediatric HIV/AIDS cases in the region.
Abstract

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