Single concentration loss of activity assay provides an improved assessment of drug-drug interaction risk compared to

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Diagonal Method to Measure Synergy Among Any Number of Drugs
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Simon G Wong1, Mey Lee1, Bradley K Wong1

  • 1a Department of Pharmacokinetics and Drug Metabolism , Amgen , South San Francisco , CA , USA.

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
|March 10, 2016
PubMed

Keywords:
Drug–drug interactionIC50IC50-shiftP450mechanism-based inactivationrisk assessmenttime-dependent inhibition

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